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A review of the regulatory status of DMAA found that "1,3-Dimethylamylamine DMAA is a pressor amine often found in food supplements for athletes at dosages of mg. Historically, the compound has been used as a nasal decongestant but its oral application is largely unstudied leaving the regulatory status of such food supplements as unlicensed medicines undetermined.
We therefore reviewed the literature on DMAA and similar amines in order to deduce an effective oral dosage. Food supplements that exceed that limit are in fact subject to the Medicines Act and require licensing. Dosages higher than mg are expected to cause serious adverse events.
The death of Claire Squires, a runner who collapsed near the finish-line of the April London Marathon , has been linked to methylhexanamine.
The coroner stated that methylhexanamine was "probably an important factor" during the inquest. Despite, according to a friend, having been diagnosed with an irregular heartbeat  - and advised not to consume methylhexanamine, it is believed that she consumed the substance through drinking an energy drink, which was subsequently adjusted to exclude methylhexanamine.
A number of sporting authorities and countries have banned or heavily restricted the use of methylhexanamine as a dietary supplement, due to serious concerns about its safety. These countries include the U. Many professional and amateur sports bodies, such as the World Anti Doping Agency , have banned methylhexanamine as a performance-enhancing substance and suspended athletes that have used it.
In , the US military issued a recall of all methylhexanamine-containing products from all military exchange stores worldwide.
In July , Health Canada decided methylhexanamine was not a dietary substance, but was a drug requiring further approval. Consequently, Health Canada banned all sales of methylhexanamine. In June , the National Food Agency of Sweden issued a general warning regarding use of methylhexanamine products, resulting in a sales ban in parts of the country.
In July , the National Health Surveillance Agency of Brazil issued a warning to the general public on the hazards of products that contain methylhexanamine. In , Australia banned methylhexanamine. In New South Wales, methylhexanamine was classed as a "highly dangerous substance" on the poisons list. In the New Zealand Ministry of Health banned the sale of methylhexanamine products,  due in part to its growing recreational use as party pills.
In April , the US Food and Drug Administration determined that methylhexanamine was potentially dangerous and did not qualify as a legal dietary supplement ; it warned supplement makers that it was illegal to market methylhexanamine and warned consumers of potentially serious health risks associated with methylhexanamine-containing products.
From Wikipedia, the free encyclopedia. Methylhexanamine Clinical data Synonyms Methylhexaneamine, methylhexamine, geranamine, geranium extract, geranium oil, 2-aminomethylhexane, dimethylamylamine, DMAA, 1,3-dimethylamylamine, 1,3-DMAA, 1,3-dimethylpentylamine, 4-methylhexanamine, 4-methylhexylamine Routes of administration Nasal spray , oral ATC code None. National Center for Biotechnology Information.
Identification and Related Records. Retrieved 27 May Archives of Internal Medicine. Issues Warning on Workout Supplement".
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