A warm welcome to the Claudius Therme.


With our feel-good cuisine, we would also like to do justice to all aspects of individual pleasure and thus offer dishes that are vegetarian, vegan or suitable for those with food allergies. The physiotherapy department of the Claudius Therme is right next to our main entrance. Unlike in fever, hyperthermia is not caused by endogenous pyrogens that change the thermoregulation set point in the brain. If the gestation is greater than 37 weeks, and if there is no other contraindication such as a malpresentation or a previous caesarean section, induction of labour should be performed.

Principal objectives


It is a trypanosome of the sub-genus Herpetosoma Stercoraria section. A parasite of rats Rattus rattus and Rattus norvegicus , that is transmitted by fleas: Nosopsyllus fasciatus , in temperate countries, and Xenopsylla cheopis in inter-tropical areas [ 1 ]. Rats are infected principally by oral route, through contamination by flea faeces or ingestion of fleas [ 2 ]. Some Herpetosoma , like the mouse trypanosome Trypanosoma musculi , have a similar strict host specificity, but others, like Trypanosoma rangeli , can infect a wide range of hosts [ 1 ].

All trypanosomes of the sub-genus Herpetosoma are non-pathogenic to their vertebrate host, it has even been reported that rats infected by T. However, it has been suggested that infection of rats by T. We have found that serial passages from mixed infections of rats with T. Obviously, in using rat models to research trypanosomosis, it is important to confirm that rats used are free of infection with other trypanosomes such as T.

Since morphological discrimination can be problematic, a molecular test to discriminate between Trypanosoma species is therefore desirable. In the course of a research project aimed at developing primers for the detection and identification of livestock trypanosomes, which were directed at the ITS1 of the ribosomal DNA, a set of intermediary primers proved to be especially sensitive for detection of T. The PCR products from T. Serial passages of a T.

Once the infection by T. Identification of the trypanosomes was performed by microscopic observation of fresh rat blood and stained blood smears. Identification was based on the morphological features of the parasites described by Hoare [ 1 ]. Sample DNA was prepared from rat buffy-coats as previously described [ 5 ]. Primer sequences were as follows: ITS1 sequences obtained with T.

In subsequent passages, T. Screening of the colony for eventual infection by T. In irradiated rats, T. In fresh preparations, the adult form of T.

The posterior end of the parasite is very thin, long and rigid, which clearly differentiates it from T. A better distinction is given by the microscopic observation of Giemsa stained blood smears, where the parasites appear as described by Hoare [ 1 ].

Trypanosoma lewisi left and Trypanosoma vivax right adult blood forms. Trypanosoma lewisi has a long thin posterior end, with a sub terminal ovale kinetoplast, the nucleus is in the anterior part of the body, part of the flagellum is free; Right: Trypanosoma vivax has a round posterior end, with a terminal round kinetoplast, the nucleus is in the medium part of the body dividing form on the right of the picture ; part of the flagellum is free.

Trypanosoma lewisi , adult forms before or after division in rat blood. Ovale kinetoplast transversal to the body clearly visible. Trypanosoma lewisi , intermediate forms in rat blood. Intermediate form with migration of the kinetoplast, large and granular body. Trypanosoma lewisi , dividing epimastigote and amastigote forms in rat blood.

Dividing epimastigote form with large body and 2 kinetoplasts and amastigote form resulting from division. Trypanosoma lewisi , adult form in rat blood. Thin posterior end, sub terminal ovale kinetoplast, nucleus in the anterior part of the body, free flagellum. In adult forms, it is noticeable that the thin straight posterior end of the parasite retains very few stains and may not be clearly visible.

Over-staining can help to make it more visible. Immature forms offer several morphological features: In early passages, when T. In further passages, the specific product of T. The length of this product clearly differentiates T. Sequence of the ITS1 underlined. A serial dilution of a DNA sample indicated that T. The sequence obtained is presented in figure 7. Alignment of the ITS1 sequences obtained in T. Comparisons of the ITS1 sequence of T. Observation of 5 normal rats randomly selected from the colony did not show the presence of T.

It has been described that natural infection of rats by T. As shown by the irradiation of 20 non-injected rats, most of the animals from the colony were already infected at the age of 4 months.

Elimination of the adult rats, insecticide treatments, and restarting of the colony from breeding stocks born after the insecticide treatments were necessary to clear the rat colony from trypanosome infection. Time limit is exhausted. Find us on iTunes!

October 17, Definition: Intermittent muscle cramps likely related to salt deficiency Heat Edema: Swelling of the feet and ankles typically in non-acclimatized people Heat Syncope: Caused by peripheral vasodilation of decrease venous return Prickly Heat: Additionally, patients can have both infection and heat stroke concomitantly.

It is not unreasonable to administer broad spectrum antibiotics if there is a suspicion for an infectious process. Disposition All patients with heat stroke should be admitted to a critical care unit to monitor for rebound hyperthermia, electrolyte abnormalities and multi system organ dysfunction Heat Exhaustion Young otherwise healthy patients can typically be discharged home Older patients with significant comorbid conditions should be considered for admission Be cautious in discharging patients if they are going to be at risk for recurrent hyperthermia i.

Ferris EB et al. Emergency treatment of exertional heatstroke and comparison of whole body cooling techniques. Med Sci Sports Exerc. Whole-body cooling of hyperthermic runners: Am J Emerg Med. Cooling methods for heatstroke victims.





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